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专家人才

  • 姓名: 舒晓东
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: shu_xiaodong@gibh.ac.cn
  • 通讯地址 广州萝岗区科学城开源大道190号

    简历:

  • 1996-2002  University of Southern California博士

    1993-1996  北京大学硕士

    1989-1993  复旦大学学士

    专业工作经历

    2007-至今 中国科学院广州生物医药与健康研究院 研究员,副研究员

    2002-2007 University of California, Los Angeles 博士后

    研究领域:

  •   实验室的主要研究方向包括:(1)上皮-间充质转换(EMT)在细胞命运调控(胚胎干细胞、肿瘤干细胞)中的作用机制研究;(2)上皮细胞极性建立、维持的机制研究及相关疾病模型(炎症性肠病及其它感染性疾病);(3)基于EMT及铁死亡通路的药物研发。

      实验室研究工作主要得到国家自然科学基金、中科院百人计划、中科院先导专项、国家重大科学研究计划、广东省科技计划等项目的经费支持。

    承担科研项目情况:

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    社会任职:

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    获奖及荣誉:

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    代表论著:

  • [1] Zhao, S., Xia, J., Wu, X., Zhang, L., Wang, P., Wang, H., Li, H., Wang, X., Chen, Y., Agnetti, J., Li, Y., Pei, D*., and Shu, X*. (2018) Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish, Nat Commun 9, 2639.

    [2] Liu, Y., Wu, F., Liu, D., Wei, R., Abbas, N., Xia, J., Li, D., Wang, H., Zhuang, Y., Guo, D., Chen, Y., Wu, Y., Ke, X., Tao, J., Yang, F., Lai, K., Shu, X., and Li, Y. X. (2018) Generation of WAe001-A-15, a human embryonic stem cell line with miR-122 doxycycline-inducible expression, Stem Cell Res 29, 84-87.

    [3] Jiang, J., Tang, S., Xia, J., Wen, J., Chen, S., Shu, X., Huen, M. S. Y., and Deng, Y. (2018) C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/beta-catenin signaling, Oncogene 37, 2992-3005.

    [4] Cao, S., Yu, S., Li, D., Ye, J., Yang, X., Li, C., Wang, X., Mai, Y., Qin, Y., Wu, J., He, J., Zhou, C., Liu, H., Zhao, B., Shu, X., Wu, C., Chen, R., Chan, W., Pan, G., Chen, J., Liu, J., and Pei, D. (2018) Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency, Cell Stem Cell 22, 529-542 e525.

    [5] Xu, J., Zhang, L., Ye, Y., Shan, Y., Wan, C., Wang, J., Pei, D., Shu, X*., and Liu, J*. (2017) SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding, Structure 25, 1251-1263 e1255.

    [6] Shan, Y., Liang, Z., Xing, Q., Zhang, T., Wang, B., Tian, S., Huang, W., Zhang, Y., Yao, J., Zhu, Y., Huang, K., Liu, Y., Wang, X., Chen, Q., Zhang, J., Shang, B., Li, S., Shi, X., Liao, B., Zhang, C., Lai, K., Zhong, X., Shu, X., Wang, J., Yao, H., Chen, J., Pei, D., and Pan, G. (2017) PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naive ESCs, Nat Commun 8, 672.

    [7] Li, Q., Hutchins, A. P., Chen, Y., Li, S., Shan, Y., Liao, B., Zheng, D., Shi, X., Li, Y., Chan, W. Y., Pan, G., Wei, S., Shu, X*., and Pei*, D. (2017) A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes, Nat Commun 8, 15166.

    [8] Cao, S., Yu, S., Chen, Y., Wang, X., Zhou, C., Liu, Y., Kuang, J., Liu, H., Li, D., Ye, J., Qin, Y., Chu, S., Wu, L., Guo, L., Li, Y., Shu, X., Chen, J., Liu, J., and Pei, D. (2017) Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage, J Biol Chem 292, 19122-19132.

    [9] Shu, X*., and Pei*, D. (2016) Pluripotency without Proliferation, Cell 164, 595-597. (preview)

    [10] Li, C., Ma, W., Yin, S., Liang, X., Shu, X., Pei, D., Egan, T. M., Huang, J., Pan, A., and Li, Z. (2016) Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3, Traffic 17, 500-514.

    [11] Xu, T., Xu, J., Ye, Y., Wang, Q., Shu, X., Pei, D., and Liu, J. (2014) Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis, Proteins 82, 3483-3489.

    [12] Shu, X*., and Pei*, D. (2014) The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming, Current opinion in genetics & development 28, 32-37. (review)

    [13] Zhang, L., Qin, D., Hao, C., Shu, X*., and Pei, D*. (2013) SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells, Cell Regeneration 2, 3.

    [14] Xu, J., Xu, T., Wu, B., Ye, Y., You, X., Shu, X., Pei, D., and Liu, J. (2013) Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation, J Biol Chem 288, 16598-16605.

    [15] Liu, N., Li, Z., Pei, D., and Shu, X*. (2013) Zfyve9a regulates the proliferation of hepatic cells during zebrafish embryogenesis, Int J Dev Biol 57, 773-778.

    [16] Yin, W., Liu, D., Liu, N., Xu, L., Li, S., Lin, S., Shu, X*., and Pei*, D. (2012) SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1, Cell Regeneration C7 - 4 1, 1-10.

    [17] Xu, L., Yin, W., Xia, J., Peng, M., Li, S., Lin, S., Pei, D*., and Shu, X*. (2012) An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish, Hepatology 55, 1985-1993.

    [18] Chen, Y., Wu, B., Xu, L., Li, H., Xia, J., Yin, W., Li, Z., Shi, D., Li, S., Lin, S., Shu, X*., and Pei, D*. (2012) A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo, Cell Res 22, 333-345.

    [19] Shu, X., Huang, J., Dong, Y., Choi, J., Langenbacher, A., and Chen, J. N. (2007) Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterning, Development 134, 1921-1930.

    [20] Cibrian-Uhalte, E., Langenbacher, A., Shu, X., Chen, J. N., and Abdelilah-Seyfried, S. (2007) Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance, J Cell Biol 176, 223-230.

    [21] Langenbacher, A. D., Dong, Y., Shu, X., Choi, J., Nicoll, D. A., Goldhaber, J. I., Philipson, K. D., and Chen, J. N. (2005) Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish, Proc Natl Acad Sci U S A 102, 17699-17704.

    [22] Wu, W., Shu, X., Hovsepyan, H., Mosteller, R. D., and Broek, D. (2003) VEGF receptor expression and signaling in human bladder tumors, Oncogene 22, 3361-3370.

    [23] Shu, X., Cheng, K., Patel, N., Chen, F., Joseph, E., Tsai, H. J., and Chen, J. N. (2003) Na,K-ATPase is essential for embryonic heart development in the zebrafish, Development 130, 6165-6173.

    [24] Shu, X., Wu, W., Mosteller, R. D., and Broek, D. (2002) Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases, Mol Cell Biol 22, 7758-7768.

    [25] Das, B., Shu, X., Day, G. J., Han, J., Krishna, U. M., Falck, J. R., and Broek, D. (2000) Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding, J Biol Chem 275, 15074-15081.

    [26] Han, J., Luby-Phelps, K., Das, B., Shu, X., Xia, Y., Mosteller, R. D., Krishna, U. M., Falck, J. R., White, M. A., and Broek, D. (1998) Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav, Science 279, 558-560.