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专家人才

  • 姓名: 张健存
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: zhang_jiancun@gibh.ac.cn
  • 通讯地址 

    简历:

    • 1985-1990 美国University of Pittsburgh有机化学博士
      1984-1985 中山大学英语培训中心英语培训
      1980-1984 复旦大学学士

    • 2005- 至今 中国科学院广州生物医药与健康研究院,研究员
      2000-2004 上海交通大学药学院,教授
      2002-2004 清华源兴生物医药与科技公司,首席科学官
      1992-2001 Gilead Sciences公司,资深科学家
      1990-1992 Duke大学博士后

    研究领域:

    • 我们的研究应用现代化学技术致力于研究和开发人类和社会需求的创新药物。
    • 包括:
      1. 研究和开发新型特别是以核苷类小分子为基础的化学药物;
      2. 合理设计和合成及天然产物的合成和修饰小分子抗癌药物
      3. 寡聚核苷酸衍生物的设计和合成
      4. 药物合成工艺及新有机合成方法的研究。

    承担科研项目情况:

  • undefined

    社会任职:

  • 广东省药学会药物化学专业委员会副主任委员,深圳生物医药孵化器专家

    获奖及荣誉:

    代表论著:

  •  

    (1) Yu Zhao, Deyao Li, Liwen Zhao, Jiancun Zhang* A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400 Synthesis, 2011, 20, 873

    (2) Liwen Zhao, Kemei Tao, Haitian Li and Jiancun Zhang*  Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines  Tetrahedron, 2011, in print

    (3) Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang,* and Qiang Zhu* A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines. J. AM. CHEM. SOC. 2010, 132 (38), 13217–13219. (IF=8.580)

    (4) YIN BIAOLIN; LIU ZHAOGUI; ZHANG JIANCUN; LI ZHENGRONG  N,N '-Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds  Synthesis 2010,19, 991  (IF=2.572)

    (5)  Baishan Jiang, Kemei Tao, Wang Shen,*, Jiancun Zhang,* Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins. Tetrahedron Letters. 2010, 6342. (IF=2.660)

    (6)  Li, Deyao; Zhao, Yu; Ye, Liu; Chen, Chaonan; Zhang, Jiancun. A Formal Total Synthesis of Fostriecin by a Convergent Approach.  Synthesis  :2010, 19, 3325-3331.  (IF=2.572)

    (7)  Zhao Lingli, Jin Changjiang, Chu Youjun, Varghese Chris, Hua Shasha, Yan Feng, Miao Yong, Liu Jing, Mann David, Ding Xia, Zhang Jiancun, Wang Zhiyong, Dou Zhen, Yao Xuebiao*. Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity. Journal of Biological Chemistry, 2010, 285(4): 2488-2497   (IF=5.328)

    (8)  Kemei Tao, Jianlong Zheng, Zhaogui Liu, Wang Shen,* Jiancun Zhang * Facile synthesis of benzoxazoles from 1,1-dibromoethenes. Tetrahedron Letters. 2010, 51, 3246–3249 (IF=2.660)

    (9) Zhaogui Liu , Deyao Li , Biaolin Yin, Jiancun Zhang*,Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group. Tetrahedron Letters, 2010, 51,240–243(IF=2.660)

    (10)  Yin, Biao-Lin; Liu, Zhao-Gui; Zhang, Jian-Cun; Li, Zheng-Rong: N, N′-Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds  Tetrahedron Letters. 2008 49, 3687 (IF=2.572)

    (11)  Liu Ye, Qian Chen,* Jiancun Zhang,*, and V_eronique Michelet*, PtCl2- Catalyzed Cycloisomerization of 1,6-Enynes for the Synthesis of Substituted Bicyclo[3.1.0]hexanes. J. Org. Chem. 2009, 74, 9550–9553. (IF=3.952)

    (12) Wen Lu Liu, Jiancun Zhang *, Fa Qin Jiang, and Lei Fu,Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues. Arch. Pharm. Chem. Life Sci. 2009, 342, 577 – 583 (IF=1.429)

    (13) Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang *, Qiang Zhu * An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas. Tetrahedron Letters ,2009, 50, 6841–6843 (IF=2.538)

    (14) Jianlong Zheng, Biaolin Yin, Wenming Huang, Xiaopeng Li, Hequan Yao, Zhaogui Liu, Jiancun Zhang, Sheng Jiang. Efficient and selective cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate using catalytic bismuth(III) bromide in acetonitrile.  Tetrahedron Letters, 2009, 50, 5094–5097 (IF=2.538)

    (15) Kai Yuan, Na Li, Kai Jiang, Tongge Zhu, Yuda Huo, Chong Wang, Jing Lu, Andrew Shaw, Kelwyn Thomas, Jiancun Zhang, David Mann, Jian Liao, Changjiang Jin, and Xuebiao Yao, PinX1 Is a Novel Microtubule-binding Protein Essential for Accurate Chromosome Segregation, Journal of Biological Chemistry, 2009, 284, 23072–23082 (IF=5.52)

    (16) Biaolin Yin, Zhaogui Liu, Mingjun Yi, and Jiancun Zhang*, A n efficient method for the synthesis of disubstituted thioureas via the reaction of N, N’-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions, Tetrahedron Lett. 2008, 49, 3687 (IF=2.615)

    (17) Chen Yao, Peng Yingdan, Jiancun Zhang, Lei fu,Syntheses and biological evaluations of novel selenonucleosides, Nucleoside, Nucleotide and Nuclei Acids” 2008, 27, 1001(IF=0.723)

    (18) YIN Biao-Lin, CHEN Li, XU. Han-hong, ZHANG. Jian-Cun, WU. Yu-Lin, Synthesis and Bio-activities of Pyrazole, Pyridine Substituted Tonghaosu Analogs. Chinese Journal of Chemistry,2007, 25 (06): 808—813 (IF=0.712)

    (19)  J. Zhang, J. Shaw and M. Matteucci “an Oligonucleotide Containing a Pentathymidine 3’-thioformacetal Unit: Synthesis and Binding Studies” Bioorganic and Medicinal Chemistry Letters, 1999, 9, 319.

    (20)  J. Zhang and M. Matteucci “2-Thioquinolines as Masked Sulfhydryls, the development of a Novel Sulfur Protecting group” Tetrahedron Letters, 1999, 40, 1467.

    (21)  J. Zhang and M. Matteucci “Synthesis of a PH-mediated N-Acylsulfamide Linked Dinucleotide and Its Incorporation into an Oligonucleotide” Bioorganic and Medicinal Chemistry Letters, 1999, 9, 2213.

    (22)  J. Zhang, T. Terhost and M. Matteucci “Synthesis and Preliminary Hybridization study of a Boranophosphate-linked Oligonucleotide” Tetrahedron Letters, 1997, 38, 4957.

    (23)  J. Zhang and M. Matteucci “a Mild Method for the Synthesis of 3’-Thioformacetal Dinucleotide: the Development of Diphenylphosphinate Acetal as a Glycosylating agents” Tetrahedron Letters, 1995, 36, 8375.

    (24)  M. C. Pirrung, J. Zhang, K. Lackey, D. D. Sternbach and F. Brown “Reactions of a Cyclic Rhodium Carbenoid with Aromatic Compounds and Vinyl ethers” J. Org. Chem., 1995, 60, 2112.

    (25)  M. C. Pirrung, J. Zhang and A. T. Morehead, Jr “Dipolar Cycloaddition of Rhodium Carbenoids to Digonal Carbon. Synthesis of Isoeuparin” Tetrahedron Letters, 1994, 35, 6229.

    (26)  D. P. Curran, W. Shen, J. Zhang, S. V. Geib and C.-H. Lin “Controlling Stereochemistry in Radical addition and Cycloaddition reactions with Oppolzer’s Camphor Sultam” Heterocycles, 1994, 37, 1773.

    (27)  M. C. Pirrung and J. Zhang “Asymmetric Cycloaddition Reactions of Diazocompounds Mediated by a Binaphthophosphate Rhodium Catalyst” Tetrahedron Letters, 1992, 40, 5987.

    (28)  J. Zhang and D. P. Curran “the Cycloadditive Route to syn 1,2-Diols. The Total Syntheses of Brevicomin and (-)-Pestalotin” J. Chem. Soc., Perkin Trans. 1, 1991, 2627.

    (29)  M.C. Pirrung, J. Zhang and A. T. McPhail “Dipolar Cycloadditions of Cyclic Rhodium Carbenoids to Aromatic heterocycles” J. Org. Chem., 1991, 56, 6259.

    (30)  D. P. Curran and J. Zhang “Nucleophilic Addition and reduction of 5-Acyl and 5-Formyl-isoxazolines. A General preparation of syn and anti -dihydroxylcarbonyls” J. Chem. Soc., Perkin Trans. 1, 1991, 2613.

    (31)  D. P. Curran, W. Shen, J. Zhang and T. A. Heffner “Asymmetric Radical Addition, Cycloaddition and Annulation reactions with Oppolzer’s Camphor Sultam” J. Am. Chem. Soc., 1990, 112, 6738.

    (32)  J. Zhang “Nucleosides, Nucleotides and Nucleic Acids” and “Peptides and Proteins” in “Natural Products Synthesis”, Li Shaoshun Ed.  2004, chemistry industry publisher

    (32)  K. Tao, Y. Zhou and J.Zhang “A Practical Synthesis of Fulvoxamine”  Chinese Pharmaceutical industry, 2005, 65

    (34) 刘舒畅,张健存,陈赛娟. BCR-ABL蛋白激酶抑制剂的研究进展. 中国医药工业杂志2010, 41(4), 293-297.

    (35) 冉 旭, 白 永, 陈 尧, 姜发琴, 张健存, 傅 磊. 叠氮无环核苷的制备、表征及活性测试.中国新药杂志. 2009, 18(20), 1995-1999.

    (36) 陈 尧, 冉 旭, 张健存, 傅 磊. 苄基保护的L - 核苷的制备. 化学研究与应用. 2008, 20(6), 749-751.

    (37) 张 璇, 张健存. 抗肿瘤新药——Combretastatin A4 磷酸酯.中国药房. 2007, 18(10), 779-781.

    (38) 卢 宁, 彭英丹, 傅 磊, 张健存. 西多福韦的合成.中国新药杂志.2007, 16(16), 1272-1274.

    (39) 陶克美,周 勇,张健存.马来酸氟伏沙明的合成. 中国医药工业杂志, 2005, 36(2), 65-67

    (40) 王战会,李进,丁彦青,何玫,刘壮俊,王慧君,张克,杨洁,马世武,唐小平,何建国,潘武宾,秦华,蒋英丽,郝彬,卢洁,马爱妞,李惠丽,赵文娟,徐宇虹,张健存,王永祥,王小宁,周向军,侯金林. 人类感染的SARS病毒来源于果子狸的分子病毒学依据. 研究快报 2003