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专家人才

  • 姓名: 秦宝明
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: qin_baoming@gibh.ac.cn
  • 通讯地址 广州市开源大道190号

    简历:

  • 教育:
    2007.9-2010.6,博士,细胞生物学,中国科学院广州生物医药与健康研究院
    1994.9-1998.6,学士,生物化学与分子生物学,北京大学生命科学学院
    工作:
    2013.9-现在,研究员,中科院广州生物医药与健康研究院
    2010.7-2013.8,副研究员,中科院广州生物医药与健康研究院
    2004.9-2007.8,助理研究员,中科院广州生物医药与健康研究院 

    研究领域:

  • Metabolism and Cell Fate: 

    1-how is metabolism regulated in stem cells? 

    2-how does autophagy maintain stem cell homeostasis? 

    3-how does epigenetics integrate into metabolic regulation? 

    承担科研项目情况:

    社会任职:

    获奖及荣誉:

  • 2016年,“国家重点研发计划-干细胞及转化研究专项”首席科学家 

    2013年,“国家自然科学奖”二等奖 

    2011年,中国科学院“优秀博士学位论文” 

    2010年,中国科学院“院长优秀奖”、“优秀毕业生” 

    代表论著:

  • # Corresponding author 

    * First author 

    1-Wu Y, Li Y, Zhang H, Huang Y, Zhao P, Tang Y, Qiu X, Ying Y, Li W, Ni S, Zhang M, Liu L, Xu Y, Zhuang Q, Luo Z, Benda C, Song H, Liu B, Lai L, Liu X, Tse HF, Bao X, Chan WY, Esteban MA, Qin B#, Pei D#. (2015) Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nature Cell Biology, 17: 715-725. 

    2-Su J, Pei D, Qin B#. (2013) Roles of small molecules in somatic cell reprogramming. Acta Pharmacologica Sinica 34:719–24. 

    3-Bao X, Zhu X, Liao B, Benda C, Zhuang Q, Pei D, Qin B#, Esteban MA#. (2013) MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology 25(2):208-14. 

    4-Esteban MA*, Wang T*, Qin B*, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6:1–9. (Cover story) 

    5-Qin B, He M, Chen X, Pei D. (2006) Sorting Nexin 10 induces giant vacuoles in mammalian cells. Journal of Biological Chemistry 281 (48): 36891-6. (Cover story) 

    6-Qin B, Chen X, Zhu J, Pei D. (2005) Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Cell Research 15 (3): 212-7. 

    7-Cui P*, Qin B*, Liu N, Pan G, Pei D. (2004) Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Experimental Cell Research 293: 154-63. 

    8-Li L, Zhang Q, Yang H, Zou Q, Lai C, Jiang F, Zhao P, Luo Z, Yang J, Chen Q, Wang Y, Newsome PN, Li W, Chen S, Wang D, Siu TS, Tam S, Tse HF, Qin B, Bao X, Esteban MA, Lai L. (2017) Fumarylacetoacetate hydrolase knock-out rabbit model for hereditary tyrosinemia type 1. Journal of Biological Chemistry 292:4755–4763.  

    9-Yang J, Wang Y, Zhou T, Wong LY, Tian XY, Hong X, Lai WH, Au KW, Wei R, Liu Y, Chen LH, Liang G, Huang Z, Fan W, Zhao P, Wang X, Ibanez DP, Luo Z, Li Y, Zhong X, Chen S, Wang D, Li L, Lai L, Qin B, Bao X, Hutchins AP, Siu CW, Huang Y, Esteban MA, Tse HF. (2017) Generation of human liver chimeric mice with hepatocytes from familial hypercholesterolemia induced pluripotent stem cells. Stem Cell Reports 8:605–618.  

    10-Xu Y, Zhang M, Li W, Zhu X, Bao X, Qin B, Hutchins AP, Esteban MA. (2016) Transcriptional control of somatic cell reprogramming. Trends in Cell Biology 26:272–288. 

    11-Bao X, Wu H, Zhu X, Guo X, Hutchins AP, Luo Z, Song H, Chen Y, Lai K, Yin M, Xu L, Zhou L, Chen J, Wang D, Qin B, Frampton J, Tse HF, Pei D, Wang H, Zhang B, Esteban MA. (2014) The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Research 25:80–92.  

    12-Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. (2014) Transcriptional pause release is a rate-limiting step for somatic cell reprogramming. Cell Stem Cell 15:574–588.  

    13-Zhuang Q, Qing X, Ying Y, Wu H, Benda C, Lin J, Huang Z, Liu L, Xu Y, Bao X, Qin B, Pei D, Esteban MA. (2013) Class IIa histone deacetylases and myocyte enhancer factor 2 proteins regulate the mesenchymal-to-epithelial transition of somatic cell reprogramming. Journal of Biological Chemistry 288:12022–12031.  

    14-Esteban MA, Bao X, Zhuang Q, Zhou T, Qin B, Pei D. (2012) The mesenchymal-to-epithelial transition in somatic cell reprogramming. Current Opinion in Genetics & Development 22:423–428.  

    15-Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, Qin B, Zeng L, Esteban MA, Pan G, Pei D. (2011) The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 9:575–587.  

    16-Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D. (2011) MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. Journal of Biological Chemistry 286:17359–17364.  

    17-Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA, Pei D. (2010) A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7:51–63.  

    18-Yao D, Wu B, Qin B, Pei D (2009) PX domain and CD domain play different roles in localization and vacuolation of Sorting Nexin 10. Chinese Science Bulletin 54:3965–3971.  

    19-Pan G, Qin B, Liu N, Scholer HR, Pei D. (2004) Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation. Journal of Biological Chemistry 279:37013–37020.