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专家人才

  • 姓名: 万超
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
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  • 通讯地址 广州市科学城开源大道190号

    简历:

  •  

      博士,香港中文大学医学院生物医学学院、深圳研究院助理教授,博士生导

      师。毕业于上海交通大学医学院(瑞金医院)获得博士学位(1999-2002)。此后

      在英国贝尔法斯特女王大学医学院任博士后研究员(2003-2005),美国阿拉巴马

      大学医学院任博士后研究员、讲师(2005-2009),约翰霍普金斯大学医学院讲师

      (2009)。现为香港中文大学深圳研究院、医学院生物医学学院干细胞与再生医学

      主题研究组成员。近年来,应用转基因动物及组织特异性基因敲除动物模型系统

      开展了骨、骨髓组织发育与再生的细胞与分子学机理研究,包括HIF、 TGF-beta、

      BMP、PTEN 等信号在成体干细胞增殖与分化调控的研究等。相关工作已发表在

      Proc Natl Acad Sci USA, J Clin Invest, Cell, Nat Med, J Biol Chem,J Bone

      Miner Res,等。在本领域有影响的SCI 收录国际期刊发表论著30 余篇。合作主

      编专著2 部,参编著作4 部。曾获得英国骨科研究学会访问学者奖、日本骨科学

      会青年学者奖、国际华人骨研学会Webster Jee 青年学者奖和美国骨矿研究学会

      Harold Frost 青年学者奖等。作为合作者曾获上海市科学技术进步奖三等奖、

      中华医学科技奖二等奖等。目前担任10 余家相关专业学术期刊的审稿专家、国

      家自然科学基金委评审专家、深圳市科技专家局评审专家等。先后承担或参与香

      港研究资助局项目,国家自然科学基金-香港研究资助局联合项目,国家自然科

      学基金重点、面上项目等多项课题的研究。主要研究方向包括组织器官修复低氧

      微环境的分子调控,成体干细胞分化的信号传导与调控,血管生成在组织再生中

      的基础与应用研究等。

    研究领域:

    承担科研项目情况:

    社会任职:

    获奖及荣誉:

    代表论著:

  •   1. Tsang WP, Shu Y, Kwok PL, Zhang F, Lee KKH, Tang MK, Li G, Chan KM,

      Chan WY, Wan C. CD146+ human umbilical cord perivascular cells maintain

      stemness under hypoxia and as a cell source for skeletal regeneration. PLoS

      One. 2013;8(10):e76153.

      2. Liu W, Li X, Zhao Y, Meng XM, Wan C, Yang B, Lan HY, Lin HY, Xia Y.

      Dragon (RGMb) inhibits E-Cadherin expression and induces apoptosis in

      renal tubular epithelial cells. J Biol Chem. 2013; 288(44):31528-39.

      3. Meng F, Rui Y, Xu L, Wan C, Jiang X, Li G. Aqp1 enhances migration of

      bone marrow mesenchymal stem cells through regulation of FAK and

      β-catenin. Stem Cells Dev. 2013 Sep 27. [Epub ahead of print]

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      4. Yao D, Xie XH, Wang XL, Wan C, Lee YW, Chen SH, Pei DQ, Wang YX, Li

      G, Qin L. Icaritin, an exogenous phytomolecule, enhances osteogenesis but not

      angiogenesis-an in vitro efficacy study. PLoS One. 2012; 7(8):e41264.

      5. Zhu XM, Wang YX, Leung KC, Lee SF, Zhao F, Wang DW, Lai JM, Wan C,

      Cheng CH, Ahuja AT. Enhanced cellular uptake of aminosilane-coated

      superparamagnetic iron oxide nanoparticles in mammalian cell lines. Int J

      Nanomedicine. 2012,7:953-64.

      6. Zhang W, Shen X, Wan C, Zhao Q, Zhang L, Zhou Q, Deng L. Effects of

      insulin and insulin-like growth factor 1 on osteoblast proliferation and

      differentiation: differential signalling via Akt and ERK. Cell Biochem Funct.

      2012, 30(4):297-302.

      7. Lu L, Cheng Q, Chen J, Yang G, Wan C, Zhang Y, Li Q. The influence of

      dietary sodium on bone development in growing rats. Arch Anim Nutr. 2011,

      65(6):486-496.

      8. Bian Q, Liang QQ, Wan C, Hou W, Li CG, Zhao YJ, Lu S, Shi Q, Wang YJ.

      Prolonged upright posture induces calcified hypertrophy in the cartilage

      end-plate in rat lumbar spine. Spine (Phila Pa 1976). 2011, 36(24):2011-2020.

      9. Bian Q, Liang QQ, Hou W, Wan C, Li CG, Zhao YJ, Lu S, Shi Q, Wang YJ.

      Prolonged and repeated upright posture promotes bone formation in rat lumbar

      vertebrae. Spine (Phila Pa 1976). 2011, 36(6):E380-7.

      10. Fulzele K, Riddle RC, Digirolamo DJ, Cao X, Wan C, Chen D, Faugere MC,

      Aja S, Hussain MA, Brüning JC, Clemens TL. Insulin receptor signaling in

      osteoblasts regulates postnatal bone acquisition and body composition. Cell.

      2010, 142(2):309-319.

      11. Wan C, Shao J, Gilbert SR, Riddle RC, Long F, Johnson RS, Schipani E,

      Clemens TL. Role of HIF-1α in skeletal development. Ann N Y Acad Sci.

      2010, 1192(1):322-326.

      12. Kumar S, Wan C, Ramaswamy G, Clemens TL, Ponnazhagan S.

      Mesenchymal stem cells expressing osteogenic and angiogenic factors

      synergistically enhance bone formation in a mouse model of segmental bone

      defect. Mol Ther. 2010, 18(5):1026-1034.

      13. Weinstein RS, Wan C, Liu QL, Wang Y, Almeida M, O’Brien CA, Thostenson

      J, Roberson PK, Boskey AL, Clemens TL,

      Manolagas SC.

      Endogenous

      glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and

      strength in aged mice. Aging Cell. 2010, 9(2):147-161.

      14. Shomento SH, Wan C, Cao X, Faugere MC, Bouxsein ML, Clemens TL,

      Riddle RC. Hypoxia-inducible factors 1alpha and 2alpha exert both distinct

      3

      and overlapping functions in long bone development. J Cell Biochem. 2010,

      109(1):196-204.

      15. Shen X, Wan C, Ramaswamy G, Mavalli M, Wang Y, Duvall CL, Deng LF,

      Guldberg RE, Eberhart A, Clemens TL, Gilbert SR. Prolyl hydroxylase

      inhibitors increase neoangiogenesis and callus formation following femur

      fracture in mice. J Orthop Res. 2009, 27(10):1298-1305.

      16. Tang Y, Wu X, Lei W, Pang L, Wan C, Shi Z, Zhao L, Nagy TR, Peng X, Hu

      J, Feng X, Van Hul W, Wan M, Cao X. TGF-beta1-induced migration of bone

      mesenchymal stem cells couples bone resorption with formation. Nat Med.

      2009, 15(7):757-765.

      17. Zhang F, Shi W, Qiu T, Wu X, Wan C, Wang Y, Wan M, Clemens TL, Cao X.

      Sustained BMP signaling in osteoblasts stimulates bone formation by

      promoting angiogenesis and osteoblast differentiation. J Bone Miner Res.

      2009, 24(7):1224-1233.

      18. Wan C, Gilbert SR, Wang Y, Cao XM, Shen X, Ramaswamy G, Jacobsen KA,

      Alaql ZS, Gerstenfeld LC, Einhorn TA, Eberhardt AW, Deng L, Guldberg RE,

      Clemens TL. Role of hypoxia inducible factor-1alpha pathway in bone

      regeneration. J Musculoskelet Neuronal Interact. 2008, 8(4):323-324.

      19. Zylstra CR, Wan C, Vankoevering KK, Sanders AK, Lindvall C, Clemens TL,

      Williams BO. Gene targeting approaches in mice: Assessing the roles of LRP5

      and LRP6 in osteoblasts. J Musculoskelet Neuronal Interact. 2008,

      8(4):291-293.

      20. Wang Y, Wan C, Szoke G, Ryaby JT, Li G. Local injection of thrombin-related

      peptide (TP508) in PPF/PLGA microparticles-enhanced bone formation

      during distraction osteogenesis. J Orthop Res. 2008, 26(4):539-46.

      21. Mak KK, Bi Y, Wan C, Chuang P-T, Clemens T, Young M, Yang Y. Hedgehog

      signaling in mature osteoblasts regulates bone formation and resorption by

      controlling PTHrP and RANKL expression. Dev Cell. 2008, 14(5):674-688.

      22. Jacobsen KA, Alaql ZS, Wan C, Jennifer L, Fitch BS, Mason ZD, Cole RM,

      Gilbert SR, Clemens TL, Morgan EF, Einhorn TA, Gerstenfeld LC. Bone

      formation during distraction osteogenesis is dependent on both VEGFR1 and

      VEGFR2 signaling. J Bone Miner Res. 2008, 23(5):596-609.

      23. Wan C, Gilbert SR, Wang Y, Cao XM, Shen X, Ramaswamy G, Jacobsen KA,

      Alaql ZS, Gerstenfeld LC, Einhorn TA, Guldberg RE, Deng L, Clemens TL.

      Activation of the hypoxia inducible factor pathway accelerates bone

      regeneration. Proc Natl Acad Sci USA. 2008, (105): 686-691.

      24. Wang Y, Wan C, Gilbert SR, Clemens TL. Oxygen sensing and osteogenesis.

      Ann N Y Acad Sci. 2007, 1117:1-11.

      4

      25. Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere

      M-C, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E,

      Clemens TL. The hypoxia inducible factor pathway couples angiogenesis to

      osteogenesis during skeletal development. J Clin Invest. 2007, 117 (6):

      1616-1626.

      26. Liu X, Bruxvoort K, Zylstra CR, Liu J, Cichowski R, Faugere M-C, Bouxsein

      ML, Wan C, Williams BO, Clemens TL. Lifelong accumulation of bone in

      mice lacking PTEN in osteoblasts. Proc Natl Acad Sci USA. 2007, 104(7):

      2259-2264.

      27. He Q, Wan C, Li G. Multi-potent mesenchymal stromal cells in blood. Stem

      Cells. 2007, 25(1):69-77.

      28. Chen X, Xu H, Wan C, McCaigue M, Li G. Bioreactor expansion of human

      adult bone marrow-derived mesenchymal stem cells (MSCs). Stem Cells. 2006,

      24(9):2052-2059.

      29. Wan C, He Q, Li G. Allogenic peripheral blood derived mesenchymal stem

      cells (MSCs) enhance bone regeneration in rabbit ulna critical-sized bone

      defect model. J Orthop Res. 2006, 24(4):610-618.

      30. Wan C, He Q, McCaige M, Marsh D, Li G.. Nonadherent cell population of

      human marrow culture is a complementary source of mesenchymal stem cells

      (MSCs). J Orthop Res. 2006, 24(1):21-28.