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专家人才

  • 姓名: 韩照升
  • 性别: 男
  • 职称: 研究员
  • 学历: 博士
  • 电话: 
  • 传真: 
  • 电子邮件: hanzhaosheng@gmail.com
  • 通讯地址 广州市科学城开源大道190号

    简历:

  •   教育背景

      08/1998-07/2001 哲学/医学博士

      专业:细胞和分子生物学, 北京大学医学部(原北京医科大学)

      导师:钟南山

      中国工程院院士,

      广州呼吸病研究所所长,

      呼吸疾病国家重点实验室主任,

      中华医学会前会长,

      世界卫生组织医学顾问

      09/1995-07/1998 内科学硕士

      导师: 何权赢教授,北京大学附属人民医院呼吸科

      09/1986-07/1991 山东医科大学医学系学士

      专业背景

      08/2012- 高级研究员,香雪制药公司 大分子项目

      07/2008- 07/2012 研究科学家,基因治疗中心,美国国立儿童医院研究所 / 综合癌症中心

      01/2006 -06/2008 研究科学家, 美国俄亥俄州立大学医学中心,戴维斯心肺研究所

      05/2004-12/2005 博士后研究员, 美国俄亥俄州立大学医学中心, 戴维斯心肺研究所

      11/2001-04/2004 博士后研究员,美国弗罗里达大学医学院

      导师:Edward R. Block 大学杰出教授, 医学系主任

      10/1991-08/1995 医师,山东省立医院内科

      

    研究领域:

    承担科研项目情况:

    社会任职:

    获奖及荣誉:

    代表论著:

  •   1. Peng Z, Weber C, Han Z, Scott JR, Chan M, Lin HJ. Dichotomy effects of Akt signaling in

      breast cancer. Mol cancer. 2012 Aug 24;11(1):61. Epub ahead of print

      2. Han Z, L Druhan, A Cardounel, L Chicoine. Regulation of endothelial nitric oxide production by

      protein methyltransferase's. FASEB J. 2011(published) note: conference article

      3. Natale E, Han Z, Slutzky JL, Chicoine LG. Resveratrol reverses both thromboxane A2 receptor and

      non receptor (K+) mediated pulmonary vasoconstriction. FASEB J 2009 (published) note:

      conference article

      4. Han Z, Pope AJ, Chicoine LG & Cardounel AJ. Increased ADMA/protein methylation modulates nitric

      oxide generation in hypoxic human lung microvascular endothelial cells. FASEB J 2009 (published)

      note: conference article

      5. Han Z, Varadharaj S., Jones C.I., Zweier JL, Alevriadou BR. Mitochondria-derived reactive oxygen

      species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther. 2009

      Apr;329(1):94-101. Epub 2 009 Jan 8.

      6. Han Z*, Jones C.I*. Alevriadou BR and Zweier JL Endothelial cell respiration is affected by the

      oxygen tension during shear exposure: role of mitochondria peroxynitrite. Am. J. Physiol. (cell

      physiology), 2008 Jul; 295(1):C180-91. * contribute equally

      Email: hanzhaosheng@gmail.com; hanzhsh@xphcn.com

      Phone: (020)-22211900(o); 18988918152 (c)

      7. Han, Z, Chen YR, Jones CI, Meenakshisundaram G, Zweier JL., Alevriadou BR Shear-induced

      reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular

      endothelial cells. Am. J. Physiol. (cell physiology). 2007 Mar; 292(3): C1103-12

      8. Jones CI, Zhu H, Han Z, Li Y, Alevriadou BR. Regulation of antioxidants and phase 2 enzymes by

      shear-induced reactive oxygen species in endothelial cells. Ann. Biomed Eng. 2007 May; 35(5)683-93.

      9. Han Z*, Cui Z*, Li Z, Hu H, Patel J.M., Antony V., Block E.R., Su Y. Involvement of calpaincalpastatin

      in cigarette smoke-induced inhibition of lung endothelial NOS. Am. J. Respir Cell Mol

      Biol. 2005 Nov; 33(5):513-20, * contribute equally

      10. Han Z, Su Y, Block ER. Involvement of acetylated histone 3 in cigarette extract-induced inhibition

      of nitric oxide synthase gene transcription in pulmonary artery endotelial cells. Am J of Respir and

      Crit Care Med. 2004Apr; 169(7):A395

      11. Xu Y, Wen S, Han Z, Zhong NS. The role of endotelial -1 in initial phase of airway inflammation.

      Am J of Respir and Crit Care Med. 2002 Apr; 165(8):A731

      12. Su Y, Cao, W, Han Z, Block ER. Cigarette smoke extract inhibits angiogenesis of pulmonary artery

      endothelial cells: The role of calpain. Am J Physiol Lung Cell Mol Physiol 2004 Oct;287(4):L794-800

      13. Han Z, Xu J, and Zhong NS. The expression of matrix metalloproteinase-9 within the airways in

      asthma. Respiratory Medicine 2003; 97:563-567

      14. Han Z, Xu J, and Zhong NS. TNF, Con A and mechanical Injury stimulate matrix metalloproteinase-

      9 expression in human bronchial endothelial cell. Chinese Journal of Pathophysiology. 2002;

      18(7):741-744 (in Chinese)

      15. Han, Z, Xu J, and Zhong NS. The expression of matrix metalloproteinase- 9 and the effect of

      interleukin-10 gene transfer in Balb/c mice infected by respiratory syncytial virus. Chinese Journal of

      Pathophysiology. (accepted for publication), 2002 (in Chinese)

      16. Han Z, Xu J, and Zhong NS. Clinical study of Matrix Metallopreoteinase-9 by airway biopsy from

      asthmatic subjects. Chinese Journal of Practical Internal Medicine 2002;22 (6): 331-3 (in Chinese)

      17. Han Z, Xu J., and Zhong NS. The Matrix Metalloproteinases-9 expression from lung tissue in OVA

      sensitized guinea pigs and the effect of antisense endothelin converting enzyme gene transfer. Chinese

      Journal of Tuberculosis and Respiratory Medicine 2001; 45(11):702-703 (in Chinese)

      18. Han Z, He Q. Quantitative analysis for emphysemous area using High resolution CT and its

      relationship to interlukin-8 plasma in subjects with emphysema. Chinese Journal of Practical Internal

      Medicine 2001; 47 (9): 546-547. (in Chinese)

      19. Han Z, He Q. The increased expression of matrix metalloproteinase in BALF of emphysema.

      Foreign Medicine Science-Branch of Internal Medicine 1999;17(5):122- 123 (in Chinese)

      20. Han Z, Xu J., and Zhong NS. The expression of Matrix Metalloproteinases-9 in human airway

      epithelial cell. Chinese Journal of Tuberculosis and Respiratory Medicine 2000;23(12):747-49

      21. Han Z, Xu J, Zhong NS. Matrix Metalloproteases and respiratory diseases. Foreign Medicine Science

      –Branch of Internal Medicine. 2000; 20(5):192-196 (in Chinese)

      22. Han Z, He Q. The advancement of Chronic Obstructive Pulmonary Disease (COPD) pathogenesis.

      Foreign Medicine Science -Branch of Respiratory Medicine supplement. 1998; 17(2)533-35 (in

      Chinese)