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专家人才

  • 姓名: 苏焕新
  • 性别: 男
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  • 通讯地址 Department of anatomy Li Ka Shing faculty of medicine University of Hong Kong

    简历:

  • Education and Qualifications

     

    09/2005-08/2008       The University of Hong Kong                      (Ph. D)          

     

    08/2000-08/2002       The Chinese University of Hong Kong         (M. Phil)

     

    07/1989-07/1994       Faculty of medicine, Zhejiang University     (B. Med)

     

    Postdoctoral training

     

    09/2008-Present        Postdoctoral fellow               Department of anatomy                                   Li Ka Shing faculty of medicine

    University of Hong Kong

     

    Academic appointments

     

    09/2000-08/2005       Senior lecturer                     Department of Anatomy, Faculty of medicine, Zhejiang University

     

    08/1994-08/2000       Lecturer                               Department of Anatomy, Faculty of medicine, Zhejiang University

     

    研究领域:

  • Research profile

     

    My research work mainly focuses on elucidating molecular mechanisms that control human pluripotent stem cells’ differentiation and using biomaterials and natural products to treat neurological disorders. I have published a total of 15 peer-reviewed international papers as first author or co-author in journals which are highly ranked in the field of neuroscience such as Nature Medicine, Cell Transplantation, Journal of Neurotrauma, Journal of Neurochemistry, Experimental Neurology, Journal of Biological Chemistry, Nanomedicine, etc. My current research work falls into three categories:

     

    (1). Understanding molecular pathways which drive human embryonic stem cells (ESCs) and human induced pluripotent stem cells (iPSCs) to differentiate into neural epithelial cells and specific neural subtypes. A prerequisite of clinical use of human ESCs and human iPSCs for the treatment with neurological disorders is how to regulate these pluripotent stem cells efficiently to differentiate into functional neural subtypes. With the identification of two pathways which play key roles in regulating neural differentiation, I have successfully directed human ESCs and iPSCs to regionally and functionally specialized neural cells, including cortical glutamatergic neurons, striatal medium spiny GABAergic neurons, midbrain dopamine neurons, spinal motoneurons, and region-specific astrocyte subtypes. The establishment of efficient approaches to drive pluripotent stem cells, especially iPSCs, to various neural cells, provides an important framework for the therapeutic application of human pluripotent stem cells.

     

    (2). Combining cell therapy with small molecules (e.g. lithium) and biomaterials (e.g. self-assembling peptide nanofiber scaffold) to treat neurological disorders. For many years, I have been involved in research work on cell therapy between laboratory experiments and clinical trials. Using various animal models, our studies show for the first time that lithium, a widely used anti-depressant drug, not only significantly promotes proliferation and neuronal differentiation of neural stem cells, but also strongly stimulates their secretion of various neurotrophic factors in vitro and after transplantation in vivo, providing evidence that the combination therapy involving cell transplants plus lithium may have the better potential for functional recovery. We have provided evidence that self-assembling peptide nanofiber scaffold could repair the injured optical pathway, bridge the injured spinal cord and promote the reconstruction of acutely injured brain. We are now investigating the potential application of self-assembling peptide nanofiber scaffold in cell-based therapies for neurological diseases.

     

     (3). Pharmacological targeting and drug discovery from herbal medicine for neurological diseases. Human ESCs differentiate into functional neurons and glial cells with a mechanism akin to in vivo development. Using this elegant in vitro differentiation model, we can select and test neuroprotective agents from Chinese medicine to natural products.

    The establishment of patient-derived iPSCs, which hold the same genome of patients, further provides us a powerful platform for drug screening and disease development studies. The efficient induction of patient iPSCs into specific neurons allows us to screen effective agents targeting on specific neurological disorders in a large scale. Our proficiency in establishment of animal models with various neurological disorders enables us to carry out timely and reliable in vivo assessment of those products which have been discovered by in vitro screening.

    承担科研项目情况:

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    获奖及荣誉:

    代表论著:

  • Su H, Wu Y, Yuan Q, Guo J, Zhang W, Wu W. Optimal time point for neuronal generation of transplanted neural progenitor cells in injured spinal cord following root avulsion. Cell Transplant. 2011;20(2):167-76.

     

    Su H, Zhang W, Guo J, Guo A, Yuan Q, Wu W. 2009. Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived neurotrophic factor. J. Neurochemistry 108:1385-1398.

     

    Su H, Zhang W, Guo J, Guo A, Yuan Q, Wu W. 2009. Neural progenitor cells enhance the survival and axonal regeneration of injured motoneurons after transplantation into the avulsed ventral horn of adult rats. J. Neurotrauma 26:67-80.

     

    Su H, Chu T, Wu W. 2007. Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord. Exp. Neurol. 206:296-307.

     

    Su H, Cho EY. 2003. Sprouting of axon-like processes from axotomized retinal ganglion cells induced by normal and pre-injured intravitreal optic nerve grafts. Brain Research 991:150-162.

     

    Yuan Q, Hu B, Chu TH, Su H, Zhang W, So KF, Lin Z, Wu W. Co-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration. Nitric Oxide. 2010 Dec 15;23(4):258-63.

     

    Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA, Pei D. Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem. 2010 Apr 9;285(15):11227-34.

     

    Yuan Q, Hu B, Wu Y, Chu TH, Su H, Zhang W, So KF, Lin Z, Wu W. Induction of c-Jun phosphorylation in spinal motoneurons in neonatal and adult rats following axonal injury. Brain Res. 2010 Mar 12;1320:7-15.

     

    Yuan Q, Hu B, Su H, So K, Lin Z, Wu W. 2009. GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion. J. Brachial Plex. Peripher. Nerve Inj. 25: 4-18.

     

    Guo J, Leung K, Su H, Yuan Q, Wang L, Chu TH, Zhang W, Pu K, Ng K, Wong W, Dai X, Wu W. 2009. Self assembling peptide nanofiber scaffold promotes the reconstruction of acute injured brain. Nanomedicine, 5:345-51.

    Chan K, Cai K, Su H, Hung V, Cheung M, Chiu C, Guo H, Jian Y, Chung S, Wu W, Wu E. 2008. Early detection of neurodegeneration in brain ischemia by manganese-enhanced MRI. Conf Proc IEEE Eng Med Biol Soc.2008:3884-7.

     

    Guo J, Su H, Zeng Y, Liang Y, Ellis-Behnke R, So KF, Wu W. 2007. Reknitting the spinal cord using a self-assembling peptide nanofiber scaffold to promote functional recovery. Nanomedicine, 3:311-21.

     

    Mi S, Hu B, Hahm K, Luo Y, Hui S, Yuan Q, Wong W, Wang L, Su H, Chu TH, Guo J, Zhang W, So KF, Pepinsky B, Shao Z, Graff C, Garber E, Jung V, Wu X,  Wu W. 2007. Rodent EAE model for the study of axon integrity and remyelination. Nature Protocols, DOI:10.1038/nprot.389.

     

    Guo J, Zeng Y, Liang Y, Wang L, Su H, Wu W. 2007. Cyclosporine affects the proliferation and differentiation of neural stem cells in culture. NeuroReport, 18:863-868.

     

    Mi S, Hu B, Hahm K, Luo Y, Hui S, Yuan Q, Wong W, Wang L, Su H, Chu TH, Guo J, Zhang W, So KF, Pepinsky B, Shao Z, Graff C, Garber E, Jung V, Wu X, Wu W. 2007. LINGO-1 Antagonist Promotes Spinal Cord Remyelination and Axonal Integrity in MOG-Induced Experimental Autoimmune Encephalomyelitis. Nature Medicine, 13:1228-1233.