首页 >> 中文 >> 专家人才

专家人才

  • 姓名: 彭广敦
  • 性别: 男
  • 职称: 研究员
  • 学历: 
  • 电话: 
  • 传真: 
  • 电子邮件: peng_guangdun@gibh.ac.cn
  • 通讯地址 广州市科学城开源大道190号

    简历:

  • 毕业于中国科学院上海生物化学与细胞生物学研究所,获得博士学位;在美国加州大学洛杉矶分校计算生物学研究所从事博士后研究;回国后在中国科学院上海生物化学与细胞生物学担任助理研究员、副研究员。20189月入职中国科学院广州生物医药与健康研究院,担任研究员、课题组长、博士生导师。

    研究领域:

  • 主要研究多能干细胞的时空动态分子图谱以及转化应用

    研究方向一:高通量自动化单细胞测序技术解析体内干细胞的功能分群与异质性,重绘干细胞的发育起源与命运特化机制;

    研究方向二:原位空间转录组技术解析空间功能特异的干细胞转录组特征,构建哺乳动物多能干细胞高分辨率的时空动态分子谱系;

    研究方向三:新型组织干细胞用于体外器官重建与功能修复

    承担科研项目情况:

  • 国家重点研发计划干细胞及转化研究重点专项

    中国科学院" 器官重建与制造"战略性先导科技专项

    国家自然科学基金面上项目 

    社会任职:

  • 国际干细胞学会(ISSCR)会员

    获奖及荣誉:

  • Sanofi-SIBS 2017 Distinguished Young Faculty

    ISSCR 2017 Poster Award and Travel Award

    代表论著:

  • 1.  Peng, G.*, Suo, S., Cui, G., Yu. F., Wang, R., Chen, J., Chen, S., Qian, Y., Chen, W., Tam, P.P., Han, J.D. and Jing, N. (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature (Accepted).

    2.   Liu Q., Liu K., Cui G., Huang, X., Yao, S., Guo, W., Qin, Z., Li, Y., Yang, R., Pu, W., Zhang, L., He, L., Zhao, H., Yu, W., Tang, M., Tian, X., Cai, D., Nie, Y., Hu, S., Ren, T., Qiao, Z., Huang, H., Zeng, Y.A., Jing, N., Peng, G.*, Ji, H.* and Zhou, B.* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 51, 728-738.

    3.   Yu, W., Ma, X., Xu, J., Heumüller, A.W., Fei, Z., Feng, X., Wang, X., Liu, K., Li, J., Cui, G., Peng, G., Ji, H., Li, J., Jing, N., Song, H., Lin, Z., Zhao, Y., Wang, Z., Zhou, B. and Zhang, L. (2019) VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet 15, e1007977.

    4.   Osteil, P., Studdert, J.B., Goh, H.N., Wilkie, E.E., Fan, X., Khoo, P.L., Peng, G., Salehin, N., Knowles, H., Han, J.J., Jing, N., Fossat, N. and Tam, P.P.L. (2019) Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells. Development 146,

    5.  Cheng, S., Pei, Y., He, L., Peng, G., Reinius, B., Tam, P.P.L., Jing, N. and Deng, Q. (2019) Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development. Cell Rep 26, 2593-2607.e3.

    6.   Song W, Wang R, Jiang W, Yin Q, Peng G, Yang R, Yu QC, Chen J, Li J, Cheung TH, Jing N, Zeng YA (2019) Hormones induce the formation of luminal-derived basal cells in the mammary gland. Cell Res, 29, 206-220

    7.  Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ (2018) Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation. Cell Stem Cell, 23: 586–598.e8

    8.    Peng G, Han JJ (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res, 7:

    9.   Cui G, Suo S, Wang R, Qian Y, Han JJ, Peng G*, Tam PPL*, Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ, 60: 463–472

    10. Christodoulou N, Kyprianou C, Weberling A, Wang R, Cui G, Peng G, Jing N, Zernicka-Goetz M (2018) Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation. Nature Cell Biology, 20: 1278–1289

    11.  Sibbritt, T., Ip, C. K., Khoo, P. L., Wilkie, E., Jones, V., Sun, J. Q. J., Shen, J. X., Peng, G., Han, J. J., Jing, N., Osteil, P., Ramialison, M., Tam, P. P. L., and Fossat, N. (2018). A gene regulatory network anchored by LIM homeobox 1 (LHX1) for embryonic head development. Genesis

    12.  Liu C, Wang, R, He Z, Osteil P, Yang X, Chen J, Peng G, Tam P, Jing N (2018), Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports 11, 43-57.

    13.  Yang X, Hu B, Hou Y, Qiao Y,, Wang R, Chen Y, Qian Y, Feng S, Chen J, Liu C, Peng G, Tang F and Jing N (2018). Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages. Cell Res 28(5):593-596.

    14.  Han, X#, Luo, S#, Peng, G#, Lu, JY, Cui G, Liu L, Yan P, Yin Y, Liu W, Wang R, Chang Z, Na J, Jing N*, and Shen X* (2018). Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. J Mol Cell Biol. 10:175-178.

    15.  Liu, C., Peng, G., and Jing, N. (2018). TGF-β signaling pathway in early mouse development and embryonic stem cells. Acta Biochim Biophys Sin. 50, 68-73.

    16.  Peng G (2017) Looking Back: Single-Cell Analysis, Empowering Stem Cell Studies (2017) Cell Stem Cell 20: 758 (Commentary)

    17.  Peng G, Tam P & Jing N (2017) Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies. National Science Review.

    18. Peng G* & Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo. Science China Life Science. doi:10.1007/s11427-016-0285-3

    19.  Zamir L, Singh R, Nathan E, Patrick R, Yifa O, Yahalom-Ronen Y, Arraf AA, Schultheiss TM, Suo S, Han J-DJ, Peng G, Jing N, Wang Y, Palpant N, Tam PP, Harvey RP & Tzahor E (2017) Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta. elife 6, e20994.

    20.  Chen J, Suo S, Tam PP, Han J-DJ*, Peng G* & Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nature Protocols 12, 566–580.

    21.  Song L, Chen J, Peng G, Tang K & Jing N (2016) Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling. Journal of Biological Chemistry 291, 15212–15225.

    22.  Peng G#, Suo S#, Chen J#, Chen W, Liu C, Yu F, Wang R, Chen S, Sun N, Cui G, Song L, Tam PPL, Han J-DJ & Jing N (2016) Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell 36, 681–697.

    23.  Peng G &Jing N (2016) Early embryo development and lineage determinationChinese Bulletin of Life Sciences.

    24.  Tang K, Peng G, Qiao Y, Song L & Jing N (2015) Intrinsic regulations in neural fate commitment. Development, Growth&Differentiation. 57, 109–120.

    25.  Li L, Song L, Liu C, Chen J, Peng G, Wang R, Liu P, Tang K, Rossant J & Jing N (2015) Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling. Journal of Molecular Cell Biology 7, 455–465.

    26.  Liu P, Dou X, Peng G, Han J-DJ & Jing N (2015) Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation. Genomic Data 5, 15–16.

    27. Song L, Sun N, Peng G, Chen J, Han J-DJ & Jing N (2015) Genome-wide ChIP-seq and RNA-seq analyses of Pou3f1 during mouse pluripotent stem cell neural fate commitment. Genomic Data 5, 375–377.

    28.  Liu P, Dou X, Liu C, Wang L, Xing C, Peng G, Chen J, Yu F, Qiao Y, Song L, Wu Y, Yue C, Li J, Han J-DJ, Tang K & Jing N (2015) Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate. Nature Communication 6, 6830.

    29. Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J-DJ, Li J & Jing N (2014) The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways. elife 3, 2.

    30. Li G, Bahn JH, Lee J-H, Peng G, Chen Z, Nelson SF & Xiao X (2012) Identification of allele-specific alternative mRNA processing via transcriptome sequencing. Nucleic Acids Research 40, e104–e104.

    31. Bahn JH, Lee J-H, Li G, Greer C, Peng G & Xiao X (2012) Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Research 22, 142–150.

    32.  Lee J-H, Gao C, Peng G, Greer C, Ren S, Wang Y & Xiao X (2011) Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts. Circulation Research 109, 1332–1341.

    33.  Kong L, Choi RCY, Xie HQ, Wang X, Peng G, Xie Z, Tsim KWK & Jing N (2011) Expression of the IgSF protein Kirre in the rat central nervous system. Life Sciences 88, 590–597.

    34.  Zhang Y-Q#, Guo N#, Peng G#, Wang X, Han M, Raincrow J, Chiu C-H, Coolen LM, Wenthold RJ, Zhao Z-Q*, Jing N* & Yu L* (2009) Role of SIP30 in the development and maintenance of peripheral nerve injury-induced neuropathic pain. Pain 146, 130–140.

    35.  Peng G#, Han M#, Du Y, Lin A, Yu L, Zhang Y & Jing N (2009) SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain. Journal of Biological Chemistry 284, 30138–30147.